Antibodies, Antinuclear, Anti-DNA, Anticentromere, Antiextractable Nuclear Antigen, Anti-Jo, and Antiscleroderma
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Antinuclear antibodies (ANA), anti-DNA (anti-ds DNA), antiextractable nuclear antigens (anti-ENA, ribonucleoprotein [RNP], Smith [Sm], SS-A/Ro, SS-B/La), anti-Jo (antihistidyl transfer RNA [tRNA] synthase), and antiscleroderma (progressive systemic sclerosis [PSS] antibody, Scl-70 antibody, topoisomerase I antibody).
To diagnose multiple systemic autoimmune disorders; primarily used for diagnosing systemic lupus erythematosus (SLE).
Serum collected in a red-top tube.
(Method: Indirect fluorescent antibody for ANA and anticentromere; Immunoassay multiplex flow for anti-DNA, ENA, Scl-70, and Jo-1)
ANA and anticentromere: Titer of 1:40 or less. Anti-ENA, Jo-1, and anti-Scl-70: Negative. Reference ranges for anti-DNA, anti-ENA, anti-Scl-70, and anti-Jo-1 vary widely due to differences in methods and the testing laboratory should be consulted directly.
|Negative||Less than 5 international units|
|Indeterminate||5–9 international units|
|Positive||Greater than 9 international units|