Davis's Lab & Diagnostic Tests

Creatinine, Urine, and Creatinine Clearance, Urine

Creatinine, Urine, and Creatinine Clearance, Urine is a topic covered in the Davis's Lab & Diagnostic Tests.

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Common Use:
To assess and monitor kidney function related to acute kidney injury or chronic kidney disease.

Urine from an unpreserved random or timed specimen collected in a clean plastic collection container.

Normal Findings:
(Method: Spectrophotometry)

Normal Urine Volume per 24 Hours
These ranges are very general averages and were not calculated on the basis of normal average body weights. Literature shows that expected urinary output can be estimated by a formula in which the expected output is as follows:
  • Infants: 1–2 mL/kg/hr
  • Children and adolescents: 0.5–1 mL/kg/hr
  • Adults and older adults: 1 mL/kg/hr
Newborns15–60 mL
 3–10 d100–300 mL
 11–59 d250–450 mL
 2–12 months400–500 mL
Children and Adolescents
 13 months–4 years500–700 mL
 5–7 years650–1000 mL
 8–14 years800–1400 mL
Adults and Older Adults800–2500 mL (average 1200 mL)
Normally, more urine is produced during the day than at night. With advancing age, the reverse often occurs. The total expected outcome for adults appears to remain the same regardless of age.
Urine Creatinine
AgeConventional UnitsSI Units
Urine Creatinine (Conventional Units × 8.84)
2–3 yr6–22 mg/kg/24 hr53–194 micromol/kg/24 hr
4–18 yr12–30 mg/kg/24 hr106–265 micromol/kg/24 hr
Adult male14–26 mg/kg/24 hr124–230 micromol/kg/24 hr
Adult female11–20 mg/kg/24 hr97–177 micromol/kg/24 hr
Creatinine Clearance
Creatinine Clearance (Conventional Units × 0.0167)
Children70–140 mL/min/1.73 m21.17–2.33 mL/s/1.73 m2
Adult male85–125 mL/min/1.73 m21.42–2.08 mL/s/1.73 m2
Adult female75–115 mL/min/1.73 m21.25–1.92 mL/s/1.73 m2
For each decade after 40 yrDecrease of 6–7 mL/min/1.73 m2Decrease of 0.06–0.07 mL/s/1.73 m2
The 24-hr urine volume is recorded and provided with the results of the creatinine measurement.

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