Davis's Lab & Diagnostic Tests

Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium

Antipsychotic Drugs and Antimanic Drugs: Haloperidol, Lithium is a topic covered in the Davis's Lab & Diagnostic Tests.

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Antipsychotic drugs: haloperidol (Dozic, Fortunan, Haldol, Haldol Decanoate, Haloneural, Serenace); antimanic drugs: lithium (Cibalith-S, Eskalith, Lithane, Lithobid, Lithonate, Lithotabs, PFI-Lith, Phasal)

Common Use:
To assist in monitoring subtherapuetic, therapeutic, or toxic drug levels related to medical interventions.

Serum collected in a red-top tube.

DrugRoute of AdministrationRecommended Collection Time
HaloperidolOralPeak: 3–6 hr
LithiumOralTrough: at least 12 hr after last dose; steady state occurs at 90–120 hr

Normal Findings:
(Method: Chromatography for haloperidol; ion-selective electrode for lithium)

DrugTherapeutic Range Conventional UnitsConversion to SI UnitsTherapeutic Range SI UnitsHalf-Life (hr)Volume of Distribution (L/kg)Protein Binding (%)Excretion
Haloperidol6–24 ng/mLSI units = Conventional units x 2.6616–64 nmol/L15–4018–3090Hepatic
Lithium (chronic)0.6–1.2 mEq/LSI units = Conventional units x 10.6–1.2 mmol/L18–240.7–10Renal

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