Biopsy, Breast is a topic covered in the Davis's Lab & Diagnostic Tests.

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Common Use:
To assist in establishing a diagnosis of breast disease; in the presence of breast cancer, this test is also used to assist in evaluating prognosis and management of response to therapy.

Breast tissue or cells.

Normal Findings:
(Method: Macroscopic and microscopic examination of tissue for biopsy; cytochemical or immunohistochemical for estrogen and progesterone receptors, Ki67, PCNA, P53; flow cytometry for DNA ploidy and S-phase fraction; immunohistochemical or FISH for Her-2/neu) Fluorescence in situ hybridization (FISH) is a cytogenic technique that uses fluorescent-labelled DNA probes to detect specific chromosome abnormalities. Favorable findings:

  • Biopsy: No abnormal cells or tissue.
  • DNA ploidy: Majority diploid cell population.
  • SPF: Low fraction of replicating cells in total cell population.
  • Her-2/neu, Ki67, PCNA, and P53: Negative to low percentage of stained cells.
  • Estrogen and progesterone receptors: High percentage of stained cells.

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