Analgesic, Anti-inflammatory, and Antipyretic Drugs: Acetaminophen, Acetylsalicylic Acid
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Acetaminophen (Acephen, Aceta, Apacet, APAP 500, Aspirin Free Anacin, Banesin, Cetaphen, Dapa, Datril, Dorcol, Exocrine, FeverAll, Genapap, Genebs, Halenol, Little Fevers, Liquiprin, Mapap, Myapap, Nortemp, Pain-Eze, Panadol, Paracetamol, Redutemp, Ridenol, Silapap, Tempra, Tylenol, Ty-Pap, Uni-Ace, Valorin); Acetylsalicylic acid (Anacin, ASA, Aspergum, aspirin, Bufferin, Easprin, Ecotrin, Empirin, Measurin, salicylate, Synalgos, ZORprin)
To assist in monitoring therapeutic drug levels and detect toxic levels of acetaminophen and salicylate in suspected overdose. It should be noted that acetaminophen and acetylsalicylic acid are contained in many other medications, such as cold and cough medicines.
Serum collected in a red-top tube.
|Drug||Therapeutic Range Conventional Units||Conversion to SI Units||SI Units||Half-Life||Volume of Distribution||Protein Binding||Excretion|
|Acetaminophen||5–20 mcg/mL||SI units = Conventional units × 6.62||33–132 micromol/L||1–3 hr||0.95 L/kg||10%–25% (dose dependent)||85%–95% hepatic; metabolites, renal|
|Salicylate||10–30 mg/dL (anti-inflammatory); 2–10 mg/dL (antipyretic/analgesic)||SI units = Conventional units × 0.073||0.7–2.2 mmol/L (anti-inflammatory); 0.2–0.7 mmol/L (antipyretic/analgesic)||2–3 hr||0.1–0.3 L/kg||90%–95%||1° hepatic; metabolites, renal|