Alkaline Phosphatase and Isoenzymes

Alkaline Phosphatase and Isoenzymes was found in Davis's Lab & Diagnostic Tests which delivers information on how the test works, how to accurately interpret results, and how to provide the best care to your patients before, during, and after a test.

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General

Synonym/Acronym:
Alk Phos, ALP and fractionation, heat-stabile ALP.

Common Use:
To assist in the diagnosis of liver cancer and cirrhosis, or bone cancer and bone fracture.

Specimen:
Serum (1 mL) collected in a red- or tiger-top tube. Plasma (1 mL) collected in a green-top (heparin) tube is also acceptable.

Normal Findings:
(Method: Spectrophotometry for total alkaline phosphatase, inhibition/electrophoresis for fractionation)

Total ALP	Conventional & SI Units	Bone Fraction	Liver Fraction
0–30 d
Male	75–375 units/L
Female	65–350 units/L
1–11 mo
Male	70–350 units/L
Female	80–330 units/L
1–5 yr
Male	56–350 units/L	39–308 units/L	Less than 8–101 units/L
Female	73–378 units/L	56–300 units/L	Less than 8–53 units/L
6–7 yr
Male	70–364 units/L	50–319 units/L	Less than 8–76 units/L
Female	73–378 units/L	56–300 units/L	Less than 8–53 units/L
8 yr
Male	70–364 units/L	50–258 units/L	Less than 8–62 units/L
Female	98–448 units/L	78–353 units/L	Less than 8–62 units/L
9–12 yr
Male	112–476 units/L	78–339 units/L	Less than 8–81 units/L
Female	98–448 units/L	78–353 units/L	Less than 8–62 units/L
13 yr
Male	112–476 units/L	78–389 units/L	Less than 8–48 units/L
Female	56–350 units/L	28–252 units/L	Less than 8–50 units/L
14 yr
Male	112–476 units/L	78–389 units/L	Less than 8–48 units/L
Female	56–266 units/L	31–190 units/L	Less than 8–48 units/L
15 yr
Male	70–378 units/L	48–311 units/L	Less than 8–39 units/L
Female	42–168 units/L	20–115 units/L	Less than 8–53 units/L
16 yr
Male	70–378 units/L	48–311 units/L	Less than 8–39 units/L
Female	28–126 units/L	14–87 units/L	Less than 8–50 units/L
17 yr
Male	56–238 units/L	34–190 units/L	Less than 8–39 units/L
Female	28–126 units/L	17–84 units/L	Less than 8–53 units/L
18 yr
Male	56–182 units/L	34–146 units/L	Less than 8–39 units/L
Female	28–126 units/L	17–84 units/L	Less than 8–53 units/L
19 yr
Male	42–154 units/L	25–123 units/L	Less than 8–39 units/L
Female	28–126 units/L	17–84 units/L	Less than 8–53 units/L
20 yr
Male	45–138 units/L	25–73 units/L	Less than 8–48 units/L
Female	33–118 units/L	17–56 units/L	Less than 8–50 units/L
21 yr and older
Male	35–142 units/L	11–73 units/L	0–93 units/L
Female	25–125 units/L	11–73 units/L	0–93 units/L
Values may be slightly elevated in older adults.

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